具有柔性和压电性的超薄Janus纳米纤维敷料用于伤口愈合

The healing process of infected skin lesions is often delayed by many factors including bacterial infection, excessive accumulation wound exudate, poor local perfusion, and low cell recruitment. Development dressing for efficient management promotion a great challenge. Herein, we constructed Janus nanofiber with the comprehensive capacities killing, piezoelectrical stimulation promoting fibroblast migration, exudate removal via unidirectional liquid delivery. rationally designed nanofibrous ultrathin, flexible, breathable, piezoelectric characteristics fabricated facile layer-by-layer electrostatic spinning technology. hydrophilic layer composed randomly arranged polycaprolactone/gelatin (PCL/Gel) nanofibers, while hydrophobic consists well-aligned Ag nanoparticles (Ag NPs)-doped polyvinylidene fluoride (PVDF/Ag) nanofibers. in vitro vivo experimental results demonstrate that can not only drain excess out unidirectionally kill bacteria, but also generate dynamic piezopotential under normal body motions to promote proliferation collagen deposition, angiogenesis, re-epithelialization, which accelerates rapid on mice. smart will provide new approach acceleration management.